Stop Leaving the Patient to Search the Literature

In 2024, I gave a talk about AI in healthcare. Afterward, a young doctor approached me. He'd been sitting in the audience, listening. Something clicked. He told me Europe needed its own clinical evidence platform — not another US import, not another cloud dependency, but something built here, for clinicians here, with EU compliance and data sovereignty at its core.

That doctor was Abdulrahman Ulfat. He went on to build Open Prometheus.

Today, Isaree and Open Prometheus are partnering. And it's not a standard integration announcement. It's a bet on something simple: the literature search should happen inside the clinical workflow, not in a separate tab. We integrate directly with EMRs, extract relevant context, and combine it with research to generate actionable clinical intelligence.

The Problem Is the Context Switch

Here's how it works today. A physician sees a patient. A question comes up. They leave the encounter, open a browser, navigate to PubMed or UpToDate, type a query, skim abstracts, mentally translate the result back to the patient in front of them. Then they return.

The literature was searched. But it happened somewhere else, disconnected from the patient, the conversation, the note, the care plan. The physician was the bridge. And they bridged it under time pressure, in their head.

This is not a minor inconvenience. It is a design failure. Clinical literature retrieval was built as a standalone research activity. It should be a capability embedded in the workflow where questions arise.

Clinical literature retrieval was built as a standalone research activity. It should be a capability embedded in the workflow where questions arise.

Research Comes to the Clinician

Isaree changes the direction. The clinician doesn't go to the research. The research comes to the clinician.

Here's what that looks like. A physician opens a patient case in Isaree. The conversation is transcribed on device. A SOAP note is generated. The physician types a clinical research question directly in the conversational workflow. No separate browser. No context switch. Open Prometheus retrieves the evidence from peer-reviewed literature, transparently, with every cited paper hyperlinked. One tap to the source. The physician notices the research is relevant but has no time to read it all. They ask Isaree to create a 15-minute podcast. They listen on the drive home.

From question to literature to understanding, all within the same workflow, on the same device, under the clinician's control.

This is what it means to integrate research capability into the clinical environment. The literature is retrieved, transparently cited, and left for the clinician to evaluate. The clinical decision remains with the clinician. That's the point. Open Prometheus doesn't make recommendations. It surfaces evidence. Isaree doesn't interpret results. It brings the research into the room.

Three Examples

1. The Changing Tumour Marker

An oncologist in Munich is reviewing a patient with metastatic colorectal cancer on second-line therapy. The latest labs show rising CEA after three months of stability, possible emerging resistance. The oncologist types into Isaree: "KRAS wild-type mCRC progressing on FOLFIRI plus bevacizumab, latest evidence on third-line sequencing with EGFR inhibitors after anti-angiogenic failure." Open Prometheus returns four recent studies, including a 2025 phase III trial. The oncologist reads the abstract, checks the full text, and reshapes the treatment plan for tumour board discussion the next morning. The literature loop took under 30 seconds. Same workflow. Same screen.

2. The Rural GP and the Heart Failure Patient

A GP in a rural practice in Ireland is seeing a patient with type 2 diabetes and newly diagnosed heart failure with preserved ejection fraction. The patient is on metformin and an SGLT2 inhibitor. The GP asks: "Adding a GLP-1 RA, latest evidence on mortality benefit in this population?" Open Prometheus returns three trials with full-text links. The GP reads the summaries, evaluates the evidence, and discusses the option with the patient during the same visit. No separate search session. No "I'll look into that and get back to you."

3. The On-Call Pharmacist

A hospital pharmacist in Berlin is on call. A junior doctor asks about anticoagulant dosing in a patient with declining renal function. The pharmacist opens Isaree, enters the question. Open Prometheus returns the latest ESC guideline update with the dosing table hyperlinked. The pharmacist reviews it, confirms the recommendation, annotates the record. Fifteen minutes saved. One safer prescription.

These are not hypotheticals. These are workflows our alpha clinicians are building today.

Built for Europe, From the Start

There's a deeper point here.

In spring 2026, OpenEvidence left the European market, citing regulatory uncertainty. The lesson wasn't that European clinicians don't need evidence at the point of care. It was that the available tools were built for a different regulatory reality. Compliance was retrofitted onto a US-first product. It didn't hold.

Open Prometheus was built from the ground up for EU compliance. Isaree runs on device, keeping patient data local by design. Data sovereignty isn't a feature we bolted on at the end. It's the architecture.

Data sovereignty isn't a feature we bolted on at the end. It's the architecture.

This matters because the regulatory direction is set. The EU AI Act. MDR. GDPR. These are not transitional hurdles. They are the permanent operating environment for clinical AI in Europe. Any platform that treats compliance as a retrofit will hit a wall. Any platform that treats it as the foundation will scale.

Isaree and Open Prometheus share that foundation. That's why this partnership fits.

What We're Building

We're in closed alpha, testing with over 50 clinical innovators across 18 countries, and plan to onboard 1,000 clinicians this summer.

This partnership is the first integration of an EU-native clinical evidence engine into an on-device AI agent platform. It won't be the last. But it sets the pattern: research integrated into the clinical workflow, on device, under the clinician's control, built for Europe from day one.

If you're a clinician, join the waiting list at Isaree. If you want to skip the line, come build with us at the Healthcare Hackathon in Berlin, July 8th to 10th.

For more on our approach to on-device, clinician-empowered AI, see "60,000 Reasons the Hospital AI Era Belongs to Clinicians, Not Cloud Vendors".